PublicNews18: Dr ZinX oral is a novel patented oral formulation
role of Zinc in Viral Infections
Dr ZinX oral is a novel patented oral formulation (Patent number: 2020900820) consisting of zinc and hinokitiol, both of which have been shown to have broad antiviral properties, including against coronaviruses.
Coronavirus are enveloped ribonucleic acid (RNA) viruses that were first identified in 1963. Prior to 2003, the viruses were associated with mild upper respiratory tract infections in humans .
Dr ZinX However, in the last two decades, three novel human coronaviruses, the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), the Middle East respiratory syndrome-associated coronavirus (MERS-CoV), and presently the severe acute respiratory syndrome-associated coronavirus-
(SARS COVID-2) Dr ZinX have caused severe diseases leading to hospitalizations and deaths . SARS COVID-2 is responsible for the ongoing coronavirus disease (COVID-19) pandemic that so far has infected more than 1.6 million people globally and caused more than 100,000 deaths .
Consequently, the pressure for a treatment and/or vaccine against coronaviruses is enormous.
Dr ZinX Human coronaviruses infects the respiratory and digestive tract epithelia, including the nasal and oral cavity mucosa, by attaching to the angiotensin converting enzyme-2 (ACE-2) membrane receptor present on the epithelial cells in these regions. The virus then rapidly replicate before spreading to the lungs and small intestines as demonstrated by large quantities of SARS-CoV RNA in the throat (9.58 x 102 to 5.93 x 106 copies/mL) and saliva (7.08 x 103 to 6.38 x 108 copies/mL) early in the infection process.
If replication is arrested at this stage, severe disease can be potentially averted and viral shedding minimized since coronaviruses, including SARS-CoV-2, are transmitted primarily through dispersal of oral and nasal droplets, and in sputum when speaking, coughing, and sneezing. This has important public health implications in reducing risk of human-human spread of the virus by reducing the viral load of the virus in oral and nasal secretions.
Role of zinc in viral infections
Zinc coronavirus is the second most abundant trace metal in the human body, and is essential in many cellular processes including DNA synthesis and RNA transcription .
Zinc coronavirus is also an integral component of many viral enzymes, underlining the significance of regulating body zinc distribution to inhibit viral replication and dissemination . Since viruses similarly require zinc to invade the body cells, an intact anti-microbial system utilizing available free away from invading viruses is necessary.
As an antiviral agent, high intracellular zinc levels (within the safe environment of macrophages) is toxic to most viruses .
Zinc deficiency is common, especially among older patients, and those with pre-existing comorbidities, who are also at greater risk of severe coronavirus disease (COVID-19). Zinc deficiency in such patients compromises the response of the immune system to viral infections.
Dr ZinX Oral Spray Through weakening innate and adaptive immune responses, zinc deficiency diminishes the capacity of the body to combat pathogens. As a consequence, zinc-deficient individuals experience an increased susceptibility to a variety of infectious agents
Antiviral properties of zinc
Dr ZinX Oral Spray The antiviral activity of zinc depends on the intracellular availability of zinc . In vitro, zinc doses of > 2 μM inhibits replication of SARS-CoV by inhibiting RNA-dependent RNA polymerase zinc and may also impair folding of the viral polyprotein that lead to inseparable precursors .
Zinc also has direct antiviral properties that include stimulation of a variety of antiviral signaling events. For example, zinc levels have been associated with inhibition of IFN-l3 signaling, actions which may moderate cytokine storm associated with worse outcome in patients infected with SARS-COVID-19. These mechanisms suggest that correct zinc doses can be used to aid in the clearance of acute viral infections.
Role of hinokitiol
Hinokitiol (hk) is a zinc ionophore that accelerates the uptake of zinc inside the cell .This action increases the concentration of intracellular zinc, potentiating its antiviral activity. The continuous presence of zinc ionophore such as hk is required for zinc ions to maintain the antiviral properties. At doses of >0.2 μg/ml hk directly inhibits viral and bacterial activities A coronavirus disinfectant patent reported that a content of 0.02 to 0.2% by mass hinokitiol had antiviral properties .
Available evidence suggests that a combination of zinc and hinokitiol are synergistic in inhibiting growth of viruses including SARS-COVID. Dr ZinX has the potential to reduce the viral load in nasal and oral mucosa, effectively reducing chances of human-human transmission and severity of COVID-19.
About the writer.
Dr. Joram Nyandat is a pediatrician and public health specialist. He is currently a pediatrician and intensive care physician at the Charlotte Maxeke Johannesburg Academic Hospital.